{"id":6696,"date":"2020-11-16T16:40:51","date_gmt":"2020-11-16T15:40:51","guid":{"rendered":"https:\/\/myoceane.fr\/?p=6696"},"modified":"2020-11-16T16:50:31","modified_gmt":"2020-11-16T15:50:31","slug":"sars-cov-2-filopodial-protrusions","status":"publish","type":"post","link":"https:\/\/myoceane.fr\/index.php\/sars-cov-2-filopodial-protrusions\/","title":{"rendered":"[COVID-19] \u79d1\u5b78\u6587\u7ae0\u7b46\u8a18\uff1aSARS-CoV-2 \u8a98\u5c0e\u5bbf\u4e3b\u7d30\u80de\u7684\u7d72\u72c0\u7a81\u8d77 (Filopodial Protrusions) \u4ee5\u4fc3\u9032\u75c5\u6bd2\u7684\u6563\u64ad"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n\n<p>\u79d1\u5b78\u6587\u7ae0\u7b46\u8a18<\/p>\n\n\n\n<p>\u4e3b\u984c\uff1aSARS-CoV-2 \u8a98\u5c0e\u5bbf\u4e3b\u7d30\u80de\u7684\u7d72\u72c0\u7a81\u8d77 (Filopodial Protrusions) \u4ee5\u4fc3\u9032\u75c5\u6bd2\u7684\u6563\u64ad<br>\u79d1\u5b78\u6587\u7ae0\u6a19\u984c\uff1aThe Global Phosphorylation Landscape of SARS-CoV-2 Infection<br>\u4f5c\u8005\uff1aBouhaddou&nbsp;<em>et al.<\/em><br>\u51fa\u8655\uff1aCell<br>\u51fa\u7248\uff1a2020\u5e746\u670828\u65e5<\/p>\n\n\n\n<p>\u9019\u7bc7\u6587\u7ae0\u662f\u5229\u7528\u975e\u6d32\u7334\u5b50\u7684\u814e\u81df\u4e0a\u76ae\u7d30\u80de (Vero E6 cells) \u505a\u5be6\u9a57\uff0c\u56e0\u70ba\u6b64\u7d30\u80de\u5c0d SARS-CoV-2 \u654f\u611f\u6027\u5f88\u9ad8\u3002\u4f5c\u8005\u5229\u7528\u5b9a\u91cf\u8cea\u8b5c\u7684\u78f7\u9178\u5316\u86cb\u767d\u8cea\u7d44\u5b78\u8abf\u67e5 (quantitative mass spectrometry-based phosphoproteomics survey)\uff0c\u63ed\u793a\u78f7\u9178\u5316 (phosphorylation) \u5c0d\u5bbf\u4e3b\u548c\u75c5\u6bd2\u86cb\u767d\u7684\u5f71\u97ff\u3002<\/p>\n\n\n\n<p>\u6b64\u7bc7\u6587\u7ae0\u89c0\u5bdf\u5230\uff0c\u75c5\u6bd2\u611f\u67d3\u5f8c\u76848\u5c0f\u6642\u958b\u59cb\uff0c\u5373\u6709\u660e\u986f\u7684\u75c5\u6bd2\u8907\u88fd\uff0c\u4f46\u572824\u5c0f\u6642\u5167\uff0c\u50c5\u89c0\u5bdf\u5230\u5bbf\u4e3b\u86cb\u767d\u5fae\u5c0f\u7684\u8b8a\u5316\u3002\u53cd\u4e4b\uff0c\u86cb\u767d\u8cea\u78f7\u9178\u5316\u4e2d\uff0c\u89c0\u5bdf\u5230\u986f\u8457\u7684\u8b8a\u5316\u3002\u6b64\u7d50\u679c\u7a81\u986f\u4e86\u75c5\u6bd2\u5229\u7528\u5bbf\u4e3b\u5f8c\u8f49\u8b6f\u8abf\u63a7\u7cfb\u7d71 (host post-translational regulatory systems)\uff0c\u4fc3\u9032\u7d30\u80de\u4fe1\u865f\u50b3\u5c0e\u5feb\u901f\u8b8a\u5316\u3002\u800c\u5bbf\u4e3b\u78f7\u9178\u5316\u7684\u8b8a\u5316\uff0c\u53cd\u6620\u4e86\u5728\u611f\u67d3\u904e\u7a0b\u4e2d\u6fc0\u9176 (kinases) \u6d3b\u6027\u7684\u6539\u8b8a\u3002<\/p>\n\n\n\n<p>SARS-CoV-2\u611f\u67d3\uff1a<br>1. \u4fc3\u9032 Casein kinase II (CK2) \u548c p38 MAPK \u7684\u6d3b\u5316<br>2. \u591a\u7a2e\u7d30\u80de\u6fc0\u7d20 (Cytokines) \u7684\u7522\u751f<br>3. \u6709\u7d72\u5206\u88c2\u76f8\u95dc\u6fc0\u9176\u7684\u95dc\u9589\uff0c\u9032\u800c\u5c0e\u81f4\u7d30\u80de\u9031\u671f\u505c\u6eef<\/p>\n\n\n\n<p>\u6b64\u5916\uff0c\u4f5c\u8005\u70ba\u7814\u7a76\u5728\u4eba\u985e\u611f\u67d3\u6a21\u578b\u4e2d\u7684\u76f8\u95dc\u6027\uff0c\u5229\u7528\u4eba\u985e\u5927\u8178\u4e0a\u76ae\u7d30\u80de Caco-2\uff08\u4eba\u985e\u611f\u67d3\uff09\uff0c\u8b49\u5be6 SARS-CoV-2\u611f\u67d3\u660e\u986f\u7684\u589e\u52a0 CK2-containing \u7684\u7d72\u72c0\u7a81\u8d77 \uff08\u6539\u8b8a\u5bbf\u4e3b\u7684\u7d30\u80de\u9aa8\u67b6\uff09\uff0c\u6b64\u7d72\u72c0\u7a81\u8d77\u53ef\u9032\u884c\u75c5\u6bd2\u9846\u7c92\u7684\u51fa\u82bd\u751f\u6b96 (budding)\uff08\u6b64\u73fe\u8c61\u4e5f\u5728Vero E6\u7d30\u80de\u4e2d\u89c0\u5bdf\u5230\uff09\u3002\u96d6\u7136\u4f5c\u8005\u5728\u6b64\u7bc7\u6587\u7ae0\u4e26\u6c92\u6709\u76f4\u63a5\u7d50\u679c\u986f\u793a\u6b64\u7d72\u72c0\u7a81\u8d77\u7269\u53ef\u4fc3\u9032\u75c5\u6bd2\u7684\u6563\u64ad\uff0c\u4f46\u4f5c\u8005\u63d0\u5230\uff0c\u5df2\u7d93\u8a31\u591a\u75c5\u6bd2\uff08\u5305\u62ec\u725b\u75d8 vaccinia\u3001Ebola \u75c5\u6bd2\u548c Marburg \u75c5\u6bd2\uff0c\u90fd\u5229\u7528\u6b64\u5bbf\u4e3b\u7d30\u80de\u7684\u9aa8\u67b6\uff0c\u5f9e\u800c\u4fc3\u9032\u4e86\u75c5\u6bd2\uff0c\u5feb\u901f\u7684\u5728\u5bbf\u4e3b\u4e0a\u76ae\u55ae\u5c64\u7d30\u80de\u9593\u7684\u6d41\u51fa\u548c\u7d30\u80de\u9593\u7684\u5feb\u901f\u64f4\u6563\u3002<\/p>\n\n\n\n<p>\u4f5c\u8005\u4e5f\u767c\u73fe p38\uff0cCK2\uff0cCDK\uff0cAXL\u548cPIKFYVE 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(budding)\u3002<\/p>\n","protected":false},"author":3,"featured_media":6698,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215,16,218],"tags":[1011,1010,182,1014,1013,1012],"class_list":["post-6696","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19","category-health","category-218","tag-covid","tag-filopodial-protrusions","tag-sars-cov-2","tag-virus","tag-1013","tag-1012"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>[COVID-19] \u79d1\u5b78\u6587\u7ae0\u7b46\u8a18\uff1aSARS-CoV-2 \u8a98\u5c0e\u5bbf\u4e3b\u7d30\u80de\u7684\u7d72\u72c0\u7a81\u8d77 (Filopodial Protrusions) \u4ee5\u4fc3\u9032\u75c5\u6bd2\u7684\u6563\u64ad - \u60f3\u65b9\u6d89\u6cd5 - \u91cf\u74f6\u5916\u7684\u5929\u7a7a M-Y-Oceane<\/title>\n<meta name=\"description\" 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