{"id":3797,"date":"2020-04-15T02:38:56","date_gmt":"2020-04-15T00:38:56","guid":{"rendered":"https:\/\/myoceane.fr\/?p=3797"},"modified":"2020-04-26T00:49:21","modified_gmt":"2020-04-25T22:49:21","slug":"covid-19%e7%a7%91%e5%ad%b8%e6%96%87%e7%ab%a0%e7%ad%86%e8%a8%98-sars-cov-2%ef%bc%88%e6%96%b0%e5%9e%8b%e5%86%a0%e7%8b%80%e7%97%85%e6%af%92%ef%bc%89%e5%8f%af%e6%84%9f%e6%9f%93t%e6%b7%8b%e5%b7%b4","status":"publish","type":"post","link":"https:\/\/myoceane.fr\/index.php\/covid-19%e7%a7%91%e5%ad%b8%e6%96%87%e7%ab%a0%e7%ad%86%e8%a8%98-sars-cov-2%ef%bc%88%e6%96%b0%e5%9e%8b%e5%86%a0%e7%8b%80%e7%97%85%e6%af%92%ef%bc%89%e5%8f%af%e6%84%9f%e6%9f%93t%e6%b7%8b%e5%b7%b4\/","title":{"rendered":"[COVID-19] \u79d1\u5b78\u6587\u7ae0\u7b46\u8a18\uff1a SARS-CoV-2\uff08\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\uff09\u53ef\u611f\u67d3T\u6dcb\u5df4\u7403"},"content":{"rendered":"
<\/div>\n\n

\u79d1\u5b78\u6587\u7ae0\u7b46\u8a18<\/strong>
\u4e3b\u984c\uff1aSARS-CoV-2\u75c5\u6bd2\u53ef\u85c9\u7531\u68d8\u86cb\u767d\u9020\u6210\u819c\u878d\u5408\u800c\u611f\u67d3T\u6dcb\u5df4\u7403 (SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion)
\u4f5c\u8005\uff1aWang et al.<\/em>
\u51fa\u8655\uff1aCell Mol Immunol
\u51fa\u7248\uff1a2020\u5e744\u67087\u65e5<\/p>\n\n\n\n

COVID-19\u70ba\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\u75be\u75c5\uff0c\u7531SARS-CoV-2\u6b64\u7a2eRNA\u75c5\u6bd2\u611f\u67d3\u3002SARS-CoV-2\u53ef\u85c9\u7531ACE2\uff08angiotensin-converting enzyme 2\uff0c\u8840\u7ba1\u7dca\u5f35\u7d20\u8f49\u5316\u91762\uff09\uff08\u8a3b\u4e00\uff09\u53d7\u9ad4\u9032\u5165\u5bbf\u4e3b\uff08\u4eba\u985e\uff09\u3002\u9664\u4e86\u5982\u80ba\u708e\uff0c\u8179\u7009\uff0c\u547c\u5438\u56f0\u96e3\u548c\u591a\u91cd\u5668\u5b98\u8870\u7aed\u7b49\u7684\u81e8\u5e8a\u75c7\u72c0\uff0c\u6dcb\u5df4\u7403\u7d30\u80de\u6e1b\u5c11\u75c7\u4e5f\u662fCOVID-19\u5e38\u898b\u7684\u81e8\u5e8a\u5fb5\u72c0\u3002<\/p>\n\n\n\n

SARS-CoV-2\uff08pseudotyped\uff0cSARS-CoV-2\u75c5\u6bd2\u7684\u5047\u578b\uff0c\u4f5c\u70ba\u6b64\u6b21\u7814\u7a76\u7684\u75c5\u6bd2\u6a21\u578b\uff09\u4e0d\u53ea\u611f\u67d3\u5177ACE2\u53d7\u9ad4\u7684293T\/ACE2\u548cHuh7\u7d30\u80de\u682a\uff0c\u4e5f\u53ef\u4ee5\u611f\u67d3\u4e0d\u5177ACE2\u53d7\u9ad4\uff08\u6216\u6975\u4f4e\u91cf\uff09\u7684\uff34\u6dcb\u5df4\u7403\uff08MT-2\u548cA3.01\u7d30\u80de\u682a\uff09\u3002\u800cSARS-CoV-2\u5c0dT\u6dcb\u5df4\u7403\u7684\u611f\u67d3\u80fd\u529b\u986f\u8457\u7684\u9ad8\u65bcSARS-CoV\uff08\u8a3b\u4e8c\uff09\u3002\u5728MT-2 \u7d30\u80de\u4e2d\u89c0\u5bdf\u5230\uff0cSARS-CoV-2\u7684\u68d8\u86cb\u767d\uff08S\u86cb\u767d\uff1bSpike protein\uff1b\u8a3b\u4e09\uff09\u6291\u5236\u5291 — EK1\u80dc\u80bd\uff08\u6291\u5236\u68d8\u86cb\u767d\u611f\u67d3\u7d30\u80de\uff09\uff0c\u53ef\u4ee5\u964d\u4f4e\u75c5\u6bd2\u611f\u67d3T\u6dcb\u5df4\u7403\u3002\u800c\u8868\u73fe\u68d8\u86cb\u767d\u7684293T\u7d30\u80de\u682a\uff0c\u53ef\u4ee5\u548cMT-2\u7d30\u80de\u878d\u5408\uff0c\u518d\u6b21\u6697\u793a\u8457SARS-CoV-2\u53ef\u85c9\u7531\u68d8\u86cb\u767d\u611f\u67d3T\u6dcb\u5df4\u7403\u3002\u6b64\u5916\uff0cSARS-CoV-2\u611f\u67d324\u5c0f\u6642\u5f8c\uff0c\u5927\u7d0423%\uff34\u6dcb\u5df4\u7403\u8868\u73fe\u6b64\u75c5\u6bd2\u7684\u6838\u6bbc\u86cb\u767d\uff08Nucleoprotein\uff0cN\u86cb\u767d\uff09\u3002\u800c\u5c07\u6b64\u75c5\u6bd2\u8207T\u6dcb\u5df4\u7403\u540c\u6642\u57f9\u990a\uff0c\u7d04\u5728\u516d\u5c0f\u6642\u5927\u91cf\u7684\u7d30\u80de\u958b\u59cb\u88ab\u611f\u67d3\uff0c\u4f46\u75c5\u6bd2\u7121\u6cd5\u5728\u7d30\u80de\u4e2d\u8907\u88fd\u3002<\/p>\n\n\n\n

\u7e3d\u7d50\uff1a
1) SARS-CoV-2\u53ef\u4ee5\u611f\u67d3T\u6dcb\u5df4\u7403
2) SARS-CoV-2\u611f\u67d3T\u6dcb\u5df4\u7403\u662f\u85c9\u7531\u68d8\u7cd6\u86cb\u767d\u548c\u5bbf\u4e3b\u7d30\u80de\u819c\u878d\u5408
3) EK1\u80dc\u80bd\u53ef\u6291\u5236\u6b64\u75c5\u6bd2\u611f\u67d3\uff34\u6dcb\u5df4\u7403<\/strong><\/p>\n\n\n\n

\u8a3b\u4e00\uff1aACE2\u70ba\u4e00\u7a2e\u5b58\u5728\u65bc\u80ba\u3001\u52d5\u8108\u3001\u5fc3\u81df\u3001\u814e\u81df\u548c\u8178\u7684\u7d30\u80de\u8868\u9762\u7684\u9175\u7d20\uff0c\u63d0\u4f9b\u90e8\u5206\u51a0\u72c0\u75c5\u6bd2\u9032\u5165\u9ede\u81f3\u5bbf\u4e3b\u5167\u3002
\u8a3b\u4e8c\uff1aSARS-CoV\u75c5\u6bd2\u70ba\u9020\u62102003\u5e74SARS\u7684\u75c5\u6bd2\u682a\u3002
\u8a3b\u4e09\uff1aSARS-CoV-2\uff0c\u7531\u56db\u500b\u7d50\u69cb\u86cb\u767d\u7d44\u6210\uff08\u5982\u5716\uff09\uff0c\u5305\u62ec\u68d8\uff08S\uff09\u86cb\u767d\uff0c\u5c01\u5957\uff08E\uff09\u86cb\u767d\uff0c\u819c\uff08M\uff09\u86cb\u767d\u548c\u6838\u6bbc\uff08N\uff09\u86cb\u767d\u3002 \u68d8\u86cb\u767d\u662f\u51a0\u72c0\u75c5\u6bd2\u6700\u91cd\u8981\u7684\u8868\u9762\u86cb\u767d\uff0c\u53ef\u901a\u904e\u8207\u7d30\u80de\u8868\u9762ACE2\u53d7\u9ad4\uff0c\u5165\u4fb5\u547c\u5438\u9053\u4e0a\u76ae\u7d30\u80de\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Reference:<\/strong>
Wang X, Xu W, Hu G, Xia S, Sun Z, Liu Z, Xie Y, Zhang R, Jiang S, Lu L (2020) SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion. Cell Mol Immunol <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u7e3d\u7d50\uff1a
\n1) SARS-CoV-2\u53ef\u4ee5\u611f\u67d3T\u6dcb\u5df4\u7403
\n2) SARS-CoV-2\u611f\u67d3T\u6dcb\u5df4\u7403\u662f\u85c9\u7531\u68d8\u7cd6\u86cb\u767d\u548c\u5bbf\u4e3b\u7d30\u80de\u819c\u878d\u5408
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